The results of meniscal allograft transplantation surgery: what is success?

BACKGROUND: Meniscal allograft transplantation (MAT) may improve symptoms and function, and may limit premature knee degeneration in patients with symptomatic meniscal loss. The aim of this retrospective study was to examine patient outcomes after MAT and to explore the different potential definitions of 'success' and 'failure'. METHODS: Sixty patients who underwent MAT between 2008 and 2014, aged 18-50 were identified. Six validated outcome measures for knee pathologies, patient satisfaction and return to sport were incorporated into a questionnaire. Surgical failure (removal of most/all the graft, revision MAT or conversion to arthroplasty), clinical failure (Lysholm < 65), complication rates (surgical failure plus repeat arthroscopy for secondary allograft tears) and whether patients would have the procedure again were recorded. Statistics analysis included descriptive statistics, with patient-reported outcome measures reported as median and range. A binomial logistic regression was performed to assess factors contributing to failure. RESULTS: Forty-three patients (72%) responded, mean age 35.6 (±7.5). 72% required concomitant procedures, and 44% had Outerbridge III or IV chondral damage. The complication rate was 21% (9). At mean follow-up of 3.4 (±1.6) years, 9% (4) were surgical failures and 21% (9) were clinical failures. Half of those patients considered a failure stated they would undergo MAT again. In the 74% (32) reporting they would undergo MAT again, median KOOS, IKDC and Lysholm scores were 82.1, 62.1 and 88, compared to 62.2, 48.5 and 64 in patients who said they would not. None of the risk factors significantly contributed to surgical or clinical failure, although female gender and number of concomitant procedures were nearly significant. Following MAT, 40% were dissatisfied with type/level of sport achieved, but only 14% would not consider MAT again. CONCLUSIONS: None of the risk factors examined were linked to surgical or clinical failure. Whilst less favourable outcomes are seen with Outerbridge Grade IV, these patients should not be excluded from potential MAT. Inability to return to sport is not associated with failure since 73% of these patients would undergo MAT again. The disparity between 'clinical failure' and 'surgical failure' outcomes means these terms may need re-defining using a specific/bespoke MAT scoring system.

Patellar chondral defect treatment with a cell-free polyglycolic acid-hyaluronan-based implant and platelet-rich fibrin glue after previously failed microfracture.

Cartilage defects of the patella are difficult to treat due to the complex anatomy of the patellofemoral joint. First-line treatment of chondral patellar defects often results in failure independent of the surgical technique. Moreover, there is no recommendation for second-line treatment of failed patellar defect treatment. Here, the case of a 48-year-old active patient with complex patellofemoral problems who had undergone multiple previous surgeries, including failed microfracture of a full-thickness cartilage defect on his patella, is presented. The patient was treated with a polymer-based implant in combination with microfracture and autologous platelet-rich fibrin glue. Post-surgical follow-up after 6 months with magnetic resonance imaging revealed complete defect filling, which was confirmed by second-look arthroscopy after 9 months, showing the formation of cartilage repair tissue. This procedure seems to be a viable and safe treatment option for patients suffering from full-thickness chondral lesions on the patella that have previously failed microfracture at the same location.

Meniscal tears, repairs and replacement: their relevance to osteoarthritis of the knee.

The menisci of the knee are important load sharers and shock absorbers in the joint. Meniscal tears are common, and whenever possible meniscal tears should be surgically repaired. Meniscectomy leads to a significant increased risk of osteoarthritis, and various options now exist for replacing missing menisci, including the use of meniscal scaffolds or the replacement of the entire meniscus by meniscal allograft transplantation. The field of meniscal surgery continues to develop apace, and the future may lie in growing new menisci by tissue engineering techniques.

The ABC of Physical Activity for Health: a consensus statement from the British Association of Sport and Exercise Sciences.

Our understanding of the relationship between physical activity and health is constantly evolving. Therefore, the British Association of Sport and Exercise Sciences convened a panel of experts to review the literature and produce guidelines that health professionals might use. In the ABC of Physical Activity for Health, A is for All healthy adults, B is for Beginners, and C is for Conditioned individuals. All healthy adults aged 18-65 years should aim to take part in at least 150 min of moderate-intensity aerobic activity each week, or at least 75 min of vigorous-intensity aerobic activity per week, or equivalent combinations of moderate- and vigorous-intensity activities. Moderate-intensity activities are those in which heart rate and breathing are raised, but it is possible to speak comfortably. Vigorous-intensity activities are those in which heart rate is higher, breathing is heavier, and conversation is harder. Aerobic activities should be undertaken in bouts of at least 10 min and, ideally, should be performed on five or more days a week. All healthy adults should also perform muscle-strengthening activities on two or more days a week. Weight training, circuit classes, yoga, and other muscle-strengthening activities offer additional health benefits and may help older adults to maintain physical independence. Beginners should work steadily towards meeting the physical activity levels recommended for all healthy adults. Even small increases in activity will bring some health benefits in the early stages and it is important to set achievable goals that provide success, build confidence, and increase motivation. For example, a beginner might be asked to walk an extra 10 min every other day for several weeks to slowly reach the recommended levels of activity for all healthy adults. It is also critical that beginners find activities they enjoy and gain support in becoming more active from family and friends. Conditioned individuals who have met the physical activity levels recommended for all healthy adults for at least 6 months may obtain additional health benefits by engaging in 300 min or more of moderate-intensity aerobic activity per week, or 150 min or more of vigorous-intensity aerobic activity each week, or equivalent combinations of moderate- and vigorous-intensity aerobic activities. Adults who find it difficult to maintain a normal weight and adults with increased risk of cardiovascular disease or type 2 diabetes may in particular benefit from going beyond the levels of activity recommended for all healthy adults and gradually progressing towards meeting the recommendations for conditioned individuals. Physical activity is beneficial to health with or without weight loss, but adults who find it difficult to maintain a normal weight should probably be encouraged to reduce energy intake and minimize time spent in sedentary behaviours to prevent further weight gain. Children and young people aged 5-16 years should accumulate at least 60 min of moderate-to-vigorous-intensity aerobic activity per day, including vigorous-intensity aerobic activities that improve bone density and muscle strength.

What tissue bankers should know about the use of allograft meniscus in orthopaedics.

The menisci of the knee are two crescent shaped cartilage shock absorbers sitting between the femur and the tibia, which act as load sharers and shock absorbers. Loss of a meniscus leads to a significant increase in the risk of developing arthritis in the knee. Replacement of a missing meniscus with allograft tissue can reduce symptoms and may potentially reduce the risk of future arthritis. Meniscal allograft transplantation is a complex surgical procedure with many outstanding issues, including 'what techniques should be used for processing and storing grafts?', 'how should the allografts be sized?' and 'what surgical implantation techniques might be most appropriate?' Further clinical research is needed and close collaboration between the users (surgeons) and the suppliers (tissue banks) is essential. This review explores the above subject in detail.

A biomechanical study of the meniscofemoral ligaments and their contribution to contact pressure reduction in the knee.

The aim of this study was to test the hypothesis that the meniscofemoral ligaments (MFLs) of the human knee assist the lateral meniscal function in reducing tibiofemoral contact pressure. Five human cadaveric knee joints were loaded in axial compression in extension using a 4-degree of freedom rig in a universal materials testing machine. Contact pressures pre- and post-sectioning of the MFLs were measured using pressure sensitive film. Sectioning the MFLs increased the contact pressure significantly in the joints for two of the four measures. In addition to their known function in assisting the posterior cruciate ligament (PCL) to resist tibiofemoral posterior drawer, the MFLs also have a significant role in reducing contact stresses in the lateral compartment. Their retention in PCL and meniscal surgery is therefore to be advised.

The effects of lateral meniscal allograft transplantation techniques on tibio-femoral contact pressures.

This paper reports a series of comparative tests in vitro, that examined how meniscectomy and meniscal allografting affected tibio-femoral joint contact pressure. Knees were loaded in axial compression and pressure maps obtained from the lateral compartment using Fuji Prescale film inserted below the meniscus. This was repeated after meniscectomy, and then after meniscal allografting with fixation by a bone plug for the insertional ligaments, plus sutures. Finally, the pressure, when the allograft was secured by sutures alone, was measured. The peak pressure rose significantly after meniscectomy, and then was reduced significantly by both allograft methods so that it was not significantly different to normal. Allografts fixed by sutures only allowed slightly higher contact pressure than when they had bone fixation. This study suggests that meniscal allografting should have a chondroprotective effect and that there is a small advantage from adding bony fixation to suture fixation.

Beyond words: the patients's unspoken messages

Patients present us with a wealth of information some of it verbal, a great deal of it non-verbal. Our diagnotic skills can be immeasurably enhanced when we are able first to notice and then to utilise the non-verbal information which patients - often unwittingly - are presenting to us. By applying the technique of 'matching' a good rapport with the patient is achieved which is quite simply the basis of all successful communication. Some pointers and exercises helpful for practioners to make the most of the non-verbal information are offered